Subclinical diabetes is a stage of hyperinsulinemia due to insulin resistance in normoglycemic individuals and, therefore, not diagnosed for hyperglycemic states characteristic of diabetes mellitus. It anticipates the prediabetes and diabetes stages characterized by hyperglycemia among other glucocentric biomarkers. Insulin resistance can be diagnosed by measures of plasma insulin, both fasting or during a glucose tolerance test - as originally reported by the pathologist Dr. Joseph R. Kraft. and Prof. Gerald Reaven. It has been endorsed by the American Diabetes Association in the Consensus Development Conference on Insulin Resistance, where they state that "if the assay for fasting insulin was reliable, it would be useful to detect insulin resistance early (i.e., before or soon after the pubertal period, which itself causes insulin resistance) and before clinical disease appears".
The implications of a permanent hyperinsulinemic stage is the risk of comorbidities related to diabetes observed in subclinical diabetic individuals including cardiovascular diseases, retinopathy, cancer, and dementia.
Video Subclinical diabetes
See also
- Prediabetes
- Impaired fasting glucose
Maps Subclinical diabetes
References
External links
- HOMA Calculator
Source of the article : Wikipedia
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